Anna campoli bmo

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Human leukocyte antigen class 1 HLA-1 �dependent immune activity is linked to autoimmune diseases. However, it remains unclear if somatic HLA-1 alterations create different magnitudes of tumor mutation burden in different tumor types 31 , NK cells assist in removal of neoplastic cells 44 , 45 and may succumb to immune exhaustion through expression of PD-1 46 , This is the first study, to our knowledge, to analyze germline HLA-1 status as a predictor of clinical benefit and toxicity in a prospective clinical trial of patients with mixed solid tumors treated with anti-PD-1 monotherapy. With the exception of prior history of autoimmune disease 10 , there are no validated biomarkers to identify which patients are likely to develop irAEs.